Endocrine Abstracts

Introduction: Serum calcium (Ca) is a major regulator of PTH secretion, but serum magnesium (Mg)also can modulate PTH secretion. Intracellular Mg depletion impairs the ability of the parathyroid to secrete PTH,which subsequently cause fall in the serum Ca concentration.Case report: A 67 year old male patient was admitted to intensive care unit because of disturbance of consciousness, due to suspected hepatic encephalopathy. In his previous history, he ha...

Introduction: Polycystic ovarian syndrome (PCOs) is a common cause of ovarian dysfunction in women with anovulation. Vitamin D plays a physiologic role in reproduction including ovarian follicular development and luteinization via altering anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production in human granulosa cells. Low vitamin D levels may exacerbate the symptoms of PCOS, including insulin resistance, ovulatory, m...

We report a case of 39–year-old female presented with painful, scaling skin lesions on insulin application sites. She was diagnosed with type 1 diabetes mellitus (T1DM) at the age of 21 years and treated with intensified conventional insulin therapy. Three months before hospital admission, she suddenly started to feel pain at insulin injection sites, followed by oval subcutaneous deposits and skin ulcer in the further course. Identical local changes repeated after subcuta...

A 65–year-old male was referred to endocrinologist due to significantly elevated calcitonin level of 3662 pg/ml. Previously, almost 3 decades before, the patient underwent right thyroid lobectomy for papillary carcinoma. Then, 9 years afterwards, he was reoperated and total thyroidectomy with neck exploration was performed. In pathohistological finding, metastatic papillary carcinoma was proved. Radioactive iodine ablation was used as a post surgical treatment. After comp...

Introduction: Gestational diabetes(GDM) is a kind of diabetes that can happen during pregnancy. Many women who have GDM, get type 2 diabetes later in life. GDM is more likely for women who are overweight, women with family members who have type 2 diabetes and women who are American Indian. During pregnancy of healthy women, it is usual for blood lipids to increase significantly. Total cholesterol, HDL- and LDL-cholesterol increase 25-50%, triglycerides increase twice to four t...

Acromegaly is chronic disease caused by hypersecretion of growth hormone (GH), most common caused by adenoma of pituitary gland. Cardiovascular risk, respiratory complication and malignancy are more common in this patients. Most often onset is between 30 to 50 years old, equally between gender. Therapy is almost always surgery, it can be combined with radiotherapy and gamma knife. Medicament therapy with somatostatin analogues, dopamine agonists and GH receptor antagonist. Goa...

Introduction: Primary hyperparathyroidism (PHPT) is disorder of one or more parathyroid glands, characterized by inadequately increased PTH secretion, almost always followed by hypercalcemia. Calcitonin, secreted by parafollicular C-cells in thyroid gland, is hypocalcemic hormone which partly acts as physiological antagonist of PTH.Aim: To evaluate calcitonin response in calcium infusion test in patients with primary hyperparathyroidism.<p class="abs...

Objective: Diabetes mellitus is among the most common of chronic disorders with increasing prevalence worldwide, affecting 50 000 citizens in Montenegro. The insulin pump is a medical device that works on the principle of continuous insulin injection, and is used in the control of diabetes in insulin dependent patients. The objective of this study was to highlight the role of nurse in education of the patients, implantation of insulin pump and nursing networking for insulin pu...

IntroductionAromatase Inhibitors (AI) are standard therapy for hormone receptor positive breast cancers in post-menopausal patients. Unfortunately, resistance is common and previous studies from our lab suggest that the altered steroid environment may be a driver. Using label-free mass spectrometry we set out to explore the unique androgen receptor (AR) interactome that supervenes in AI resistant breast cancer and associated hyper-androgenic environment....

Introduction: Diabetes mellitus is a metabolic disease which causes acute and chronic complications including insulin deficiency and ineffectiveness or both its incidence is increasing every day. Urinary tract infections are more frequently seen and can lead a more aggressive course in diabetic patients when compared with the population in general. The aim of this study is to determine antibacterial susceptibilities of Gram-negative bacteria isolated from diabetic and non-diab...